The purpose of present investigation was to enhance the dissolution behavior of a poorly water soluble drug candesartan cilexetil (CND) - an angiotensin receptor blocker, antihypertensive drug; on aqueous solubility and rate of dissolution in dissolution media, by formation of inclusion complex with β-Cyclodextrin (β-CD). The phase solubility profile for β-CD was classified as AL type, revealing 1:1 stoichiometric complexation of cyclodextrin with CND. On the basis of preliminary trials kneading was selected as method of preparation of inclusion complex. Furthermore, the complex was optimized to investigate influence of drug:polymer ratio, on the dissolution profile. In-vitro dissolution studies of optimized batch were found to exhibit better dissolution profile in comparison with plain CND. The increment in solubility and dissolution profile enhancement of CND is attributed to the decrease in drug crystallinity by entrapment in the inclusion cavity of (β-CD). The approach seems to be promising in improving the oral bioavailability of CND.
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